Acquired Coagulation Inhibitor Delaying
نویسندگان
چکیده
A 14-yr-old girl with Down syndrome develimmune sera revealed that the inhibitor was oped a unique type of circulating inhibitor an immunoglobulin of lgG class with both causing a mild bleeding tendency and interand A determinants. Isolated inhibitor defering strongly with coagulation tests, includlayed the release of fibrinopeptide A from a ing reptilase time, and with the reaction of normal fibrlnogen reacting with thrombln and purified fibrinogen and thrombin. The conretarded the onset of visible clotting, but had centration of all coagulation factors was no effect on the final degree of clottability. normal. The inhibitor had no direct effect on The clinical and laboratory features of this thrombin activity or on the aggregatIon of patient resemble those of patients with fibrin monomer in plasma. Chromatography congenital dysfibrinogenemla associated on DEAE-cellulose and neutralization by with abnormal fibrinopeptide release.
منابع مشابه
Acquired coagulation inhibitor delaying fibrinopeptide release.
A 14-yr-old girl Down syndrome developed a unique type of circulating inhibitor causing a mild bleeding tendency and interfering strongly with coagulation tests, including reptilase time, and with the reaction of purified fibrinogen and thrombin. The concentration of all coagulation factors was normal. The inhibitor had no direct effect on thrombin activity or on the aggregation of fibrin monom...
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